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Headache Pathway Calculator

Cheshire & Merseyside / Walton Centre headache pathway (adults, 2025) · NICE CG150 Headaches in over 12s · NICE TA906, TA919, TA973

Patient

Red flags

After a full history, neurological examination (including fundi and visual fields), BP, temporal arteries, pregnancy status and weight.

Headache features

Painkiller use & treatment so far

Preventatives tried adequately (at maximum tolerated dose for 3–4 months) or not tolerated or contraindicated:

NICE-recommended plan

Enter the age and tick any red flags, or describe the headache, to see the plan.

Decision support only, based on the Cheshire & Merseyside / Walton Centre adult headache pathway (2025), NICE CG150 and NICE technology appraisals. Where they differ, both are shown. Doses follow the pathway and the BNF – check the SPC, interactions and contraindications. It does not replace clinical assessment; if in doubt use the Walton Centre advice line or refer.

Quick reference

Red flags and actions
Red flagAction
Thunderclap; CNS infection signsEmergency department
New papilloedema or visual lossUrgent optician / emergency eye clinic / ED
** Only on straining, coughing or lying down; only when upright; focal deficit or cognitive change; older, cancer, immunosuppression, trauma, pregnancy/postpartum; NDPH over 3 monthsGP direct access MRI brain (CT if no MRI) – state red flag and "As per C&M headache pathway"
New headache over 50Urgent ESR/CRP; if GCA likely, steroids now and urgent referral
Painful red eye with haloesUrgent ophthalmology
Refractory (3 adequate preventatives)Gepants, then Walton Centre neurology via e-RS

Advice line: weekdays 11:30–1:30, 07860 481429.

Diagnosis at a glance
  • Migraine: moderate–severe, affects function, hours to 3 days; nausea, light or sound sensitivity, worse with activity. Mostly bilateral. Most have no aura.
  • Chronic migraine: 15 or more headache days a month for over 3 months, at least 8 severe.
  • Tension-type: mild, featureless, bilateral, doesn't limit activity.
  • Cluster: strictly one-sided around the eye with autonomic features, 1–4 hours, often at night, restless; bouts of 4–12 weeks.
  • Trigeminal neuralgia: one-sided electric-shock jabs over the lower face or jaw, triggered by touch or chewing.
  • Medication overuse: triptans or opioids on 10 or more days a month, or simple analgesics on 15 or more, for over 3 months.
  • Facial pain alone is rarely sinusitis – usually a primary headache.
Migraine treatment steps
  1. Acute: triptan, aspirin, paracetamol or NSAID – or triptan with one of these. Early, max 2 doses an attack, max 3 days a week. Antiemetic. No opioids.
  2. 2+ triptans failed or contraindicated: rimegepant acute (TA919).
  3. Prevent if 4+ migraine days a month or acute treatment over 2–3 days a week: propranolol, candesartan, amitriptyline; topiramate and valproate only in men and women 55+.
  4. 3 adequate preventatives failed: rimegepant (episodic) or atogepant (episodic or chronic).
  5. Then refer to Walton Centre for CGRP antibodies or botulinum toxin.